Research
Holth, J. K., Fritschi, S. K., Wang, C., Pedersen, N. P., Cirrito, J. R., Mahan, T. E., Finn, M. B., Manis, M., et al. (2019). The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans. SCIENCE, 363(6429), 880-884. doi:10.1126/science.aav2546
Duncan, M. J., Farlow, H., Tirumalaraju, C., Yun, D. H., Wang, C., Howard, J. A., Sanden, M. N., O’Hara, B. F., et al. (2019). Effects of the dual orexin receptor antagonist DORA-22 on sleep in 5XFAD mice. Alzheimers Dement (N Y), 5, 70-80. doi:10.1016/j.trci.2019.01.003
Goodwin, L. O., Splinter, E., Davis, T. L., Urban, R., He, H., Braun, R. E., Chesler, E. J., Kumar, V., et al. (2019). Large-scale discovery of mouse transgenic integration sites reveals frequent structural variation and insertional mutagenesis. Genome Res, 29(3), 494-505. doi:10.1101/gr.233866.117
Guerriero, R., Harrison, DA., Shaw, P., O’Hara, BF. (2019). Investigation novel-sleep related genes in Drosophila melanogaster: A follow up on KOMP2 identified genes in Mus musculus. Society for Neuroscience annual meeting, Chicago, 2019.
Hou T, W. C. J. S., O’Hara BF, Gong MC and Guo Z (2019). Active Time-Restricted Feeding Improved Sleep-Wake Cycle in db/db Mice. Front. Neurosci., 13(969).
Huffman, D., Ajwad, AA., Wang, J., Murphy MP., O’Hara, BF., Duncan, MJ. (2019). Feasibility of dynamic sleep enhancement in a mouse model of Alzheimer’s disease. Society for Neuroscience annual meeting, Chicago, 2019
Paulose, J. K., Wang, C., O’Hara, B. F., & Cassone, V. M. (2019). The effects of aging on sleep parameters in a healthy, melatonin-competent mouse model. Nat Sci Sleep, 11, 113-121. doi:10.2147/nss.S214423
Phillips, S., Xiong, H., Donohue, KD, O’Hara, BF., Lonstein, JS., Yan, L. (2019). Too sad to sleep? Sleep patterns in a rodent SAD model analyzed by the piezoelectric system. Society for Neuroscience annual meeting, Chicago, 2019.
Robinson-Junker, A., O’Hara, B., Durkes, A., & Gaskill, B. (2019). Sleeping through anything: The effects of unpredictable disruptions on mouse sleep, healing, and affect. PLoS One, 14(1), e0210620. doi:10.1371/journal.pone.0210620
Black, S. W., Sun, J. D., Santiago, P., Laihsu, A., Kimura, N., Yamanaka, A., Bersot, R., & Humphries, P. S. (2018). Partial ablation of the orexin field induces a sub-narcoleptic phenotype in a conditional mouse model of orexin neurodegeneration. Sleep, 41(9). doi:10.1093/sleep/zsy116
Maple, A. M., Rowe, R. K., Lifshitz, J., Fernandez, F., & Gallitano, A. L. (2018). Influence of Schizophrenia-Associated Gene Egr3 on Sleep Behavior and Circadian Rhythms in Mice. J Biol Rhythms, 33(6), 662-670. doi:10.1177/0748730418803802
Robinson-Junker, A. L., O’Hara B, F., & Gaskill, B. N. (2018). Out Like a Light? The Effects of a Diurnal Husbandry Schedule on Mouse Sleep and Behavior. J Am Assoc Lab Anim Sci, 57(2), 124-133.
Rowe, R. K., Harrison, J. L., Zhang, H., Bachstetter, A. D., Hesson, D. P., O’Hara, B. F., Greene, M. I., & Lifshitz, J. (2018). Novel TNF receptor-1 inhibitors identified as potential therapeutic candidates for traumatic brain injury. J Neuroinflammation, 15(1), 154. doi:10.1186/s12974-018-1200-y
DePoy, L. M., McClung, C. A., & Logan, R. W. (2017). Neural Mechanisms of Circadian Regulation of Natural and Drug Reward. Neural Plast, 2017, 5720842. doi:10.1155/2017/5720842
Karp, N. A., Mason, J., Beaudet, A. L., Benjamini, Y., Bower, L., Braun, R. E., Brown, S. D. M., Chesler, E. J., et al. (2017). Prevalence of sexual dimorphism in mammalian phenotypic traits. Nat Commun, 8, 15475. doi:10.1038/ncomms15475
O’Hara BF, P. Jiang, FW Turek, P Franken. (2017). Genetics and Genomic Basis of Sleep in Rodents. Principles and Practice of Sleep Medicine, 6th ed, 296-309.
Ajwad, A., Yaghouby, F., Huffman, D., O’Hara, B., & Sunderam, S. (2016). Effect of temperature on sleep regulation in an animal epilepsy model. Conf Proc IEEE Eng Med Biol Soc, 2016, 1644-1647. doi:10.1109/EMBC.2016.7591029
Coronas-Samano, G., Baker, K. L., Tan, W. J., Ivanova, A. V., & Verhagen, J. V. (2016). Fus1 KO Mouse As a Model of Oxidative Stress-Mediated Sporadic Alzheimer’s Disease: Circadian Disruption and Long-Term Spatial and Olfactory Memory Impairments. Front Aging Neurosci, 8, 268. doi:10.3389/fnagi.2016.00268
Bonsall, D. R., Kim, H., Tocci, C., Ndiaye, A., Petronzio, A., McKay-Corkum, G., Molyneux, P. C., Scammell, T. E., et al. (2015). Suppression of Locomotor Activity in Female C57Bl/6J Mice Treated with Interleukin-1beta: Investigating a Method for the Study of Fatigue in Laboratory Animals. PLoS One, 10(10), e0140678. doi:10.1371/journal.pone.0140678
Harrison, J. L., Rowe, R. K., Ellis, T. W., Yee, N. S., O’Hara, B. F., Adelson, P. D., & Lifshitz, J. (2015). Resolvins AT-D1 and E1 differentially impact functional outcome, post-traumatic sleep, and microglial activation following diffuse brain injury in the mouse. Brain Behav Immun, 47, 131-140. doi:10.1016/j.bbi.2015.01.001
Sethi, M., Joshi, S. S., Webb, R. L., Beckett, T. L., Donohue, K. D., Murphy, M. P., O’Hara, B. F., & Duncan, M. J. (2015). Increased fragmentation of sleep-wake cycles in the 5XFAD mouse model of Alzheimer’s disease. Neuroscience, 290, 80-89. doi:10.1016/j.neuroscience.2015.01.035
Harrison, J. L., Rowe, R. K., O’Hara, B. F., Adelson, P. D., & Lifshitz, J. (2014). Acute over-the-counter pharmacological intervention does not adversely affect behavioral outcome following diffuse traumatic brain injury in the mouse. Exp Brain Res, 232(9), 2709-2719. doi:10.1007/s00221-014-3948-3
Rowe, R. K., Harrison, J. L., O’Hara, B. F., & Lifshitz, J. (2014). Diffuse brain injury does not affect chronic sleep patterns in the mouse. Brain Inj, 28(4), 504-510. doi:10.3109/02699052.2014.888768
Rowe, R. K., Harrison, J. L., O’Hara, B. F., & Lifshitz, J. (2014). Recovery of neurological function despite immediate sleep disruption following diffuse brain injury in the mouse: clinical relevance to medically untreated concussion. Sleep, 37(4), 743-752. doi:10.5665/sleep.3582
Rowe, R. K., Striz, M., Bachstetter, A. D., Van Eldik, L. J., Donohue, K. D., O’Hara, B. F., & Lifshitz, J. (2014). Diffuse brain injury induces acute post-traumatic sleep. PLoS One, 9(1), e82507. doi:10.1371/journal.pone.0082507
Duncan, M. J., Smith, J. T., Franklin, K. M., Beckett, T. L., Murphy, M. P., St Clair, D. K., Donohue, K. D., Striz, M., et al. (2012). Effects of aging and genotype on circadian rhythms, sleep, and clock gene expression in APPxPS1 knock-in mice, a model for Alzheimer’s disease. Exp Neurol, 236(2), 249-258. doi:10.1016/j.expneurol.2012.05.011
Jiang, P., Franklin, K. M., Duncan, M. J., O’Hara, B. F., & Wisor, J. P. (2012). Distinct phase relationships between suprachiasmatic molecular rhythms, cerebral cortex molecular rhythms, and behavioral rhythms in early runner (CAST/EiJ) and nocturnal (C57BL/6J) mice. Sleep, 35(10), 1385-1394. doi:10.5665/sleep.2120
Jiang, P., Striz, M., Wisor, J. P., & O’Hara, B. F. (2011). Behavioral and genetic dissection of a mouse model for advanced sleep phase syndrome. Sleep, 34(1), 39-48. doi:10.1093/sleep/34.1.39
Philip, V. M., Sokoloff, G., Ackert-Bicknell, C. L., Striz, M., Branstetter, L., Beckmann, M. A., Spence, J. S., Jackson, B. L., et al. (2011). Genetic analysis in the Collaborative Cross breeding population. Genome Res, 21(8), 1223-1238. doi:10.1101/gr.113886.110
Wisor, J. P., Jiang, P., Striz, M., & O’Hara, B. F. (2009). Effects of ramelteon and triazolam in a mouse genetic model of early morning awakenings. Brain Res, 1296, 46-55. doi:10.1016/j.brainres.2009.07.103
Black, S. S., JD; Laihsu, A; Kimura, N; Santiago, P; Donohue, KD; O’Hara, BF; Bersot, R; Humphrie, PS. (preprint). Rapid, noninvasive, and unsupervised detection of sleep/wake using piezoelectric monitoring for pharmacological studies in narcoleptic mice bioRxiv, preprint.
Joshi, S. S., M; Striz, M; Cole, N; Denegre, JM; Ryan, J; Lhamon, ME; Agarwal, A; Murray, S; Braun, RE; Fardo, DW; Kuma, VR; Donohue, KD; Sunderam, S; Chesler, EJ; Svenson, KL; O’Hara, BF. (preprint). Noninvasive sleep monitoring in large-scale screening of knock-out mice reveals novel sleep-related genes. preprint bioRxiv. doi:https://doi.org/10.1101/517680
Duncan, M., Askarov E., Baker, A., Beechem, I., Gillis, BD., Salisbury, F., Guerriero, R., O’Hara, BF., Bachstetter, AD., Murphy, MP. (2019). The effects of fragmentation of the daily sleep-wake rhythm on amyloid-beta levels and neuroinflammation in the 3X Tg-AD mouse model of Alzheimer’s disease. Society for Neuroscience annual meeting, Chicago, 2019.
Development
Mang, G. M., Nicod, J., Emmenegger, Y., Donohue, K. D., O’Hara, B. F., & Franken, P. (2014). Evaluation of a piezoelectric system as an alternative to electroencephalogram/ electromyogram recordings in mouse sleep studies. SLEEP, 37(8), 1383-1392. doi:10.5665/sleep.3936
Huffman, D. M., Staggs, K. E., Yaghouby, F., Agarwal, A., O’Hara, B. F., Donohue, K. D., Blalock, E. M., & Sunderam, S. (2016). Tunable somatosensory stimulation for selective sleep restriction studies in rodents. Conf Proc IEEE Eng Med Biol Soc, 2016, 1640-1643. doi:10.1109/EMBC.2016.7591028
Klefot, J. M., Murphy, J. L., Donohue, K. D., O’Hara, B. F., Lhamon, M. E., & Bewley, J. M. (2016). Development of a noninvasive system for monitoring dairy cattle sleep. J Dairy Sci, 99(10), 8477-8485. doi:10.3168/jds.2015-10695
Yaghouby, F., Donohue, K. D., O’Hara, B. F., & Sunderam, S. (2016). Noninvasive dissection of mouse sleep using a piezoelectric motion sensor. J Neurosci Methods, 259, 90-100. doi:10.1016/j.jneumeth.2015.11.004
Yaghouby, F., O’Hara, B. F., & Sunderam, S. (2016). Unsupervised Estimation of Mouse Sleep Scores and Dynamics Using a Graphical Model of Electrophysiological Measurements. Int J Neural Syst, 26(4), 1650017. doi:10.1142/S0129065716500179
Yaghouby, F., Schildt, C. J., Donohue, K. D., O’Hara, B. F., & Sunderam, S. (2014). Validation of a closed-loop sensory stimulation technique for selective sleep restriction in mice. Conf Proc IEEE Eng Med Biol Soc, 2014, 3771-3774. doi:10.1109/EMBC.2014.6944444
Donohue, K. D., Medonza, D. C., Crane, E. R., & O’Hara, B. F. (2008). Assessment of a non-invasive high-throughput classifier for behaviours associated with sleep and wake in mice. Biomed Eng Online, 7, 14. doi:10.1186/1475-925x-7-14
Williams DG, K. D., BF O’Hara. (2008). Low-Frequency Amplifiers for PVDF Film Sensors. Paper presented at the IEEE, Southeast conference.
Flores, A. E., Flores, J. E., Deshpande, H., Picazo, J. A., Xie, X. S., Franken, P., Heller, H. C., Grahn, D. A., et al. (2007). Pattern recognition of sleep in rodents using piezoelectric signals generated by gross body movements. IEEE Trans Biomed Eng, 54(2), 225-233. doi:10.1109/tbme.2006.886938
Bernat, R., Lin, A-H., Agarwal, A., Donohue, KD., O’Hara, BF. (2019). Piezoelectric sensors for noninvasive breath rate tracking in a cage setting. Society for Neuroscience annual meeting, Chicago, 2019.
Huffman, D., Duque Quiceno F., Carrizosa, S., Ajwad, A., Wang, J., Johnson, E., Hargis-Staggs, K., Donohue, K., O’Hara, BF., Bauer, B., Blalock, E., Sunderam, S. (2019). Toward high-throughput, non-invasive seizure detection using piezoelectric motion. Society for Neuroscience annual meeting, Chicago, 2019.
Topchiy, I., Fink, AM., Maki, K., Calik, M. (2019). Validation of PiezoSleep scoring against EEG/EMG sleep scoring in rats. Society for Neuroscience annual meeting, Chicago, 2019.
Ajwad, A., Huffman, D., Wang, H., Moore, I., Mills, R., Yaghouby, F., Gentry, M., Pauly, J., Bauer, B., O’Hara, BF, Sunderam, S. (2018). A noninvasive screening method for seizures and related behaviors in small animal models. Society for Neuroscience annual meeting, San Diego, 2018.
Huffman, D., Ajwad, A, Agarwal, A, O’Hara, B, Donohue, K, Sunderam, S. (2018). Automated selective REM sleep restriction through noninvasive somatosensory stimulation. Sleep Meeting, 2018, Baltimore, MD.
Huffman D, A. A., Agarwal A, O’Hara BF, Donohue KD, and Sunderam S. (2018). A non-invasive alternative to selective sleep restriction in rodents using somatosensory stimulation. Society for Neuroscience annual meeting, San Diego, Nov 2018.
Mania- and anxiety-like behavior and impaired maternal care in female diacylglycerol kinase eta and iota double knockout mice https://www.ncbi.nlm.nih.gov/pubmed/?term=30985063
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