Highlights of PiezoSleep System From Recent Literature
Drug induced alterations in sleep patterns identified with the PiezoSleep system.
Researchers at the University of Texas investigated circadian and sleep altering effects of two drugs used to treat conditions with known circadian components; Verapamil is used to treat cluster headaches, which occur at roughly the same time of day for most patients, and Moricizine was previously used to treat arrhythmia, where cardiac events are known to occur more frequently in the morning.
Following identification of circadian effects of the drugs in vitro, the investigators used the PiezoSleepTM system to assess drug related changes in sleep patterns in mice, identifying alterations in the time of sleep onset, sleep bout-lengths, and in light vs dark period sleep. Verapamil, a calcium channel blocker used to treat cluster headaches, migraines, hypertension, and angina, altered the time of sleep, but not total sleep, in a sex specific manner in mice. Male mice treated with verapamil slept more in the light period; treated female mice slept more in the dark (active) period, with shorter average sleep bout durations. Verapamil reduced activity levels in both sexes, and reduced the free running period both in vitro and in vivo. In a separate study, Moricizine was found to increase the total amount of sleep in mice, particularly in the early dark period, when mice are usually most active. In vitro, Moricizine was found to lengthen the circadian cycle in a dose dependent manner.
These studies highlight the utility of the PiezoSleepTM system for efficiently investigating drug induced changes in sleep patterns without the need for surgery and EEG monitoring, facilitating higher powered studies with larger number of animals in drug screening studies, at lower cost.
Complete publications:
Clock-Modulating Activities of the Anti-Arrhythmic Drug Moricizine
The PiezoSleep system is used to evaluate SARM1 as a target for intervention in Traumatic Brain Injury
Sleep disruption is a common comorbidity of traumatic brain injury (TBI), chronically affecting approximately half of individuals who have had a mild, moderate or severe traumatic brain injury. Researchers at Uniformed Services University included the PiezoSleepTM system in a study to assess the potential of SARM1 (sterile alpha and Toll/interleukin-1 receptor motif-containing 1) as a target for therapeutic intervention following TBI. SARM1 initiates a programmed pathway that depletes energy stores and results in structural breakdown of axons following injury.
In this model of chronic TBI, atrophy of the corpus collosum, and behavior tests including sleep, were compared in TBI vs sham injured wild type (WT) and SAMR1 knock-out (KO) mice. Longitudinal MRI volumetric measurements of the corpus collosum in mice following TBI at 3 days (acute injury) and ten weeks (chronic stage), compared to baseline (pre-injury) measurements showed a higher level of atrophy in WT mice compared to SARM1 KO mice at ten weeks post-injury. In agreement with this observation, axons of SARM1 KO mice had less damage than axons of WT mice at ten weeks post-injury by multiple histological measures. Sleep studies at eight weeks post-injury identified reduced sleep in WT TBI mice compared to sham treated WT mice, whereas there was no statistical difference in percent sleep between TBI and sham treated SARM1 KO mice. Disrupted sleep in WT TBI mice occurred during the light period, or subjective night, for mice. Collectively, these results provide evidence for preservation of axon integrity and function following TBI when SARM1 is disabled, indicating SARM1 as a viable target for therapeutic intervention. Sleep monitoring indicates that sleep disruption is present in this chronic TBI mouse model, and may be a useful in vivo indicator of progressive disease. Sleep monitoring post-TBI over multiple weeks would be useful to identify when sleep disruption first appears and whether it continues, worsens, or changes over time. Noninvasive sleep tracking with PiezoSleepTM is ideal for longitudinal data collection in TBI models, where mice have already experienced brain trauma, with the added benefit of lower cost and automated data collection in multiple groups of mice.
Link to publication:
Mechanisms of homeostatic regulation of GABA type A receptors by accessory protein Shisa7, with observed differences in tonic inhibition in sleep and wake.
Researchers at the National Institute of Health investigated the role of Shisa7 in modulating tonic inhibition in the hippocampus using cultured hippocampal CA1 neurons, mouse hippocampal slices, and by comparing tonic current in sleep and wake states in Shisa7 Knockout (KO) and wild-type (WT) mice.
The results from this study provide evidence that PKA phosphorylation of Shisa7 promotes exocytosis of α5-GABAAR, thereby increasing tonic inhibition in the hippocampus via increased levels of α5-GABAAR at the extrasynaptic neuronal surface. Differences in tonic inhibition mediated by Shisa7 in sleep and wake states were investigated by measuring tonic current in hippocampal slices from WT and Shisa7 Knockout KO mice that had been in extended sleep or wake states (4 hours), monitored by the PiezoSleepTM system, at the time of sacrifice. Tonic current was found to be higher during wake than in sleep, and modulated by Shisa7, as observed by sleep vs wake differences in WT mice that were not present in Shisa7 KO mice.
Link to publication:
Activity- and sleep-dependent regulation of tonic inhibition by Shisa7
Research
Wu, K., Han, W., Tian, Q., Li, Y., Lu, W., 2021. Activity- and sleep-dependent regulation of tonic inhibition by Shisa7. Cell Rep 34, 108899.
Vanneau, T., Quiquempoix, M., Trignol, A., Verdonk, C., Van Beers, P., Sauvet, F., Gomez-Merino, D., Chennaoui, M., 2021. Determination of the sleep-wake pattern and feasibility of NREM/REM discrimination using the non-invasive piezoelectric system in rats. J Sleep Res, e13373.
Spears, L.D., Adak, S., Dong, G., Wei, X., Spyropoulos, G., Zhang, Q., Yin, L., Feng, C., Hu, D., Lodhi, I.J., Hsu, F.F., Rajagopal, R., Noguchi, K.K., Halabi, C.M., Brier, L., Bice, A.R., Lananna, B.V., Musiek, E.S., Avraham, O., Cavalli, V., Holth, J.K., Holtzman, D.M., Wozniak, D.F., Culver, J.P., Semenkovich, C.F., 2021. Endothelial ether lipids link the vasculature to blood pressure, behavior, and neurodegeneration. J Lipid Res 62, 100079.
Saber, M., Murphy, S.M., Cho, Y., Lifshitz, J., Rowe, R.K., 2021. Experimental diffuse brain injury and a model of Alzheimer’s disease exhibit disease-specific changes in sleep and incongruous peripheral inflammation. J Neurosci Res 99, 1136-1160.
Olejniczak, I., Ripperger, J.A., Sandrelli, F., Schnell, A., Mansencal-Strittmatter, L., Wendrich, K., Hui, K.Y., Brenna, A., Ben Fredj, N., Albrecht, U., 2021. Light affects behavioral despair involving the clock gene Period 1. PLoS Genet 17, e1009625.
Kim, E., Nohara, K., Wirianto, M., Escobedo, G., Jr., Lim, J.Y., Morales, R., Yoo, S.H., Chen, Z., 2021. Effects of the Clock Modulator Nobiletin on Circadian Rhythms and Pathophysiology in Female Mice of an Alzheimer’s Disease Model. Biomolecules 11.
Han, C., Wirianto, M., Kim, E., Burish, M.J., Yoo, S.H., Chen, Z., 2021. Clock-Modulating Activities of the Anti-Arrhythmic Drug Moricizine. Clocks Sleep 3, 351-365.
Burish, M.J., Han, C., Mawatari, K., Wirianto, M., Kim, E., Ono, K., Parakramaweera, R., Chen, Z., Yoo, S.H., 2021. The first-line cluster headache medication verapamil alters the circadian period and elicits sex-specific sleep changes in mice. Chronobiol Int, 1-12.
Bradshaw, D.V., Jr., Knutsen, A.K., Korotcov, A., Sullivan, G.M., Radomski, K.L., Dardzinski, B.J., Zi, X., McDaniel, D.P., Armstrong, R.C., 2021. Genetic inactivation of SARM1 axon degeneration pathway improves outcome trajectory after experimental traumatic brain injury based on pathological, radiological, and functional measures. Acta Neuropathol Commun 9, 89
Saber, M., Giordano, K.R., Hur, Y., Ortiz, J.B., Morrison, H., Godbout, J.P., Murphy, S.M., Lifshitz, J., Rowe, R.K., 2020. Acute peripheral inflammation and post-traumatic sleep differ between sexes after experimental diffuse brain injury. The European journal of neuroscience 52, 2791-2814.
Saber, M., Giordano, K.R., Hur, Y., Ortiz, J.B., Morrison, H., Godbout, J.P., Murphy, S.M., Lifshitz, J., Rowe, R.K., 2020. Acute peripheral inflammation and post-traumatic sleep differ between sexes after experimental diffuse brain injury. The European journal of neuroscience 52, 2791-2814.
Mishra, I., Pullum, K.B., Thayer, D.C., Plummer, E.R., Conkright, B.W., Morris, A.J., O’Hara, B.F. Demas, G.E., Ashley, N.T., 2020. Chemical sympathectomy reduces peripheral inflammatory responses to acute and chronic sleep fragmentation. American journal of physiology. Regulatory, integrative and comparative physiology 318, R781-R789.
Bubier, JA, Hao H., Philip V., Roy T., Monroy Hernandez C., Bernat R., Donohue D., O’Hara BF., Chesler EJ. 2020. Genetic variation regulates opioid-induced respiratory depression in mice. Scientific Reports 10: 14970.
Bubier, J.A., Philip, V.M., Quince, C., Campbell, J., Zhou, Y., Vishnivetskaya, T., Duvvuru, S., Blair, R.H., Ndukum, J., Donohue, K.D., Foster, C.M., Mellert, D.J., Weinstock, G., Culiat, C.T., O’Hara, B.F., Palumbo, A.V., Podar, M., Chesler, E.J., 2020. A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice. Genetics 214, 719-733.
Bartsch, V.B., Lord, J.S., Diering, G.H., Zylka, M.J., 2020. Mania- and anxiety-like behavior and impaired maternal care in female diacylglycerol kinase eta and iota double knockout mice. Genes, brain, and behavior 19, e12570.
Badran, M., Khalyfa, A., Ericsson, A., Gozal, D., 2020. Fecal microbiota transplantation from mice exposed to chronic intermittent hypoxia elicits sleep disturbances in naive mice. Experimental neurology 334, 113439.
Rowe, R.K., Harrison, J.L., Morrison, H.W., Subbian, V., Murphy, S.M., Lifshitz, J., 2019. Acute Post-Traumatic Sleep May Define Vulnerability to a Second Traumatic Brain Injury in Mice. J Neurotrauma 36, 1318-1334.
Robinson-Junker, A., O’Hara, B., Durkes, A., Gaskill, B., 2019. Sleeping through anything: The effects of unpredictable disruptions on mouse sleep, healing, and affect. PloS one 14, e0210620.
Phillips, S., Xiong, H., Donohue, KD, O’Hara, BF., Lonstein, JS., Yan, L., 2019. Too sad to sleep? Sleep patterns in a rodent SAD model analyzed by the piezoelectric system. Society for Neuroscience Meeting, Chicago, 2019.
Paulose, J.K., Wang, C., O’Hara, B.F., Cassone, V.M., 2019. The effects of aging on sleep parameters in a healthy, melatonin-competent mouse model. Nature and science of sleep 11, 113-121.
Onos, K.D., Uyar, A., Keezer, K.J., Jackson, H.M., Preuss, C., Acklin, C.J., O’Rourke, R., Buchanan, R., Cossette, T.L., Sukoff Rizzo, S.J., Soto, I., Carter, G.W., Howell, G.R., 2019. Enhancing face validity of mouse models of Alzheimer’s disease with natural genetic variation. PLoS Genet 15, e1008155.
Nohara, K., Mallampalli, V., Nemkov, T., Wirianto, M., Yang, J., Ye, Y., Sun, Y., Han, L., Esser, K.A., Mileykovskaya, E., D’Alessandro, A., Green, C.B., Takahashi, J.S., Dowhan, W., Yoo, S.H., Chen, Z., 2019. Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge. Nat Commun 10, 3923.
Huffman, D., Ajwad, AA., Wang, J., Murphy MP., O’Hara, BF., Duncan, MJ., 2019. Feasibility of dynamic sleep enhancement in a mouse model of Alzheimer’s disease. Society for Neuroscience Meeting, Chicago, 2019
Hou T, W.C.J.S., O’Hara BF, Gong MC and Guo Z 2019. Active Time-Restricted Feeding Improved Sleep-Wake Cycle in db/db Mice. Front. Neurosci. 13.
Holth, J.K., Fritschi, S.K., Wang, C., Pedersen, N.P., Cirrito, J.R., Mahan, T.E., Finn, M.B., Manis, M., Geerling, J.C., Fuller, P.M., Lucey, B.P., Holtzman, D.M., 2019. The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans. Science 363, 880-884.
Guerriero, R., Harrison, DA., Shaw, P., O’Hara, BF., 2019. Investigation novel-sleep related genes in Drosophila melanogaster: A follow up on KOMP2 identified genes in Mus musculus. Society for Neuroscience Meeting, Chicago, 2019.
Goodwin, L.O., Splinter, E., Davis, T.L., Urban, R., He, H., Braun, R.E., Chesler, E.J., Kumar, V., van Min, M., Ndukum, J., Philip, V.M., Reinholdt, L.G., Svenson, K., White, J.K., Sasner, M., Lutz, C., Murray, S.A., 2019. Large-scale discovery of mouse transgenic integration sites reveals frequent structural variation and insertional mutagenesis. Genome Res 29, 494-505.
Duncan, M.J., Farlow, H., Tirumalaraju, C., Yun, D.H., Wang, C., Howard, J.A., Sanden, M.N., O’Hara, B.F., McQuerry, K.J., Bachstetter, A.D., 2019. Effects of the dual orexin receptor antagonist DORA-22 on sleep in 5XFAD mice. Alzheimers Dement (N Y) 5, 70-80.
Duncan, M., Askarov E., Baker, A., Beechem, I., Gillis, BD., Salisbury, F., Guerriero, R., O’Hara, BF., Bachstetter, AD., Murphy, MP., 2019. The effects of fragmentation of the daily sleep-wake rhythm on amyloid-beta levels and neuroinflammation in the 3X Tg-AD mouse model of Alzheimer’s disease. Society for Neuroscience Meeting, Chicago, 2019.
Rowe, R.K., Harrison, J.L., Zhang, H., Bachstetter, A.D., Hesson, D.P., O’Hara, B.F., Greene, M.I., Lifshitz, J., 2018. Novel TNF receptor-1 inhibitors identified as potential therapeutic candidates for traumatic brain injury. J Neuroinflammation 15, 154.
Robinson-Junker, A.L., O’Hara B, F., Gaskill, B.N., 2018. Out Like a Light? The Effects of a Diurnal Husbandry Schedule on Mouse Sleep and Behavior. Journal of the American Association for Laboratory Animal Science : JAALAS 57, 124-133.
Maple, A.M., Rowe, R.K., Lifshitz, J., Fernandez, F., Gallitano, A.L., 2018. Influence of Schizophrenia-Associated Gene Egr3 on Sleep Behavior and Circadian Rhythms in Mice. J Biol Rhythms 33, 662-670.
Black, S.W., Sun, J.D., Santiago, P., Laihsu, A., Kimura, N., Yamanaka, A., Bersot, R., Humphries, P.S., 2018. Partial ablation of the orexin field induces a sub-narcoleptic phenotype in a conditional mouse model of orexin neurodegeneration. Sleep 41.
O’Hara BF, P.J., FW Turek, P Franken, 2017. Genetics and Genomic Basis of Sleep in Rodents. Principles and Practice of Sleep Medicine, 6th ed, 296-309.
Karp, N.A., Mason, J., Beaudet, A.L., Benjamini, Y., Bower, L., Braun, R.E., Brown, S.D.M., Chesler, E.J., Dickinson, M.E., Flenniken, A.M., Fuchs, H., Angelis, M.H., Gao, X., Guo, S., Greenaway, S., Heller, R., Herault, Y., Justice, M.J., Kurbatova, N., Lelliott, C.J., Lloyd, K.C.K., Mallon, A.M., Mank, J.E., Masuya, H., McKerlie, C., Meehan, T.F., Mott, R.F., Murray, S.A., Parkinson, H., Ramirez-Solis, R., Santos, L., Seavitt, J.R., Smedley, D., Sorg, T., Speak, A.O., Steel, K.P., Svenson, K.L., Wakana, S., West, D., Wells, S., Westerberg, H., Yaacoby, S., White, J.K., 2017. Prevalence of sexual dimorphism in mammalian phenotypic traits. Nat Commun 8, 15475.
DePoy, L.M., McClung, C.A., Logan, R.W., 2017. Neural Mechanisms of Circadian Regulation of Natural and Drug Reward. Neural Plast 2017, 5720842.
Coronas-Samano, G., Baker, K.L., Tan, W.J., Ivanova, A.V., Verhagen, J.V., 2016. Fus1 KO Mouse As a Model of Oxidative Stress-Mediated Sporadic Alzheimer’s Disease: Circadian Disruption and Long-Term Spatial and Olfactory Memory Impairments. Front Aging Neurosci 8, 268.
Ajwad, A., Yaghouby, F., Huffman, D., O’Hara, B., Sunderam, S., 2016. Effect of temperature on sleep regulation in an animal epilepsy model. Conference proceedings : … Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 2016, 1644-1647.
Sethi, M., Joshi, S.S., Webb, R.L., Beckett, T.L., Donohue, K.D., Murphy, M.P., O’Hara, B.F., Duncan, M.J., 2015. Increased fragmentation of sleep-wake cycles in the 5XFAD mouse model of Alzheimer’s disease. Neuroscience 290, 80-89.
Harrison, J.L., Rowe, R.K., Ellis, T.W., Yee, N.S., O’Hara, B.F., Adelson, P.D., Lifshitz, J., 2015. Resolvins AT-D1 and E1 differentially impact functional outcome, post-traumatic sleep, and microglial activation following diffuse brain injury in the mouse. Brain Behav Immun 47, 131-140.
Bonsall, D.R., Kim, H., Tocci, C., Ndiaye, A., Petronzio, A., McKay-Corkum, G., Molyneux, P.C., Scammell, T.E., Harrington, M.E., 2015. Suppression of Locomotor Activity in Female C57Bl/6J Mice Treated with Interleukin-1beta: Investigating a Method for the Study of Fatigue in Laboratory Animals. PloS one 10, e0140678.
Rowe, R.K., Striz, M., Bachstetter, A.D., Van Eldik, L.J., Donohue, K.D., O’Hara, B.F., Lifshitz, J., 2014. Diffuse brain injury induces acute post-traumatic sleep. PloS one 9, e82507.
Rowe, R.K., Harrison, J.L., O’Hara, B.F., Lifshitz, J., 2014. Diffuse brain injury does not affect chronic sleep patterns in the mouse. Brain Inj 28, 504-510.
Rowe, R.K., Harrison, J.L., O’Hara, B.F., Lifshitz, J., 2014. Recovery of neurological function despite immediate sleep disruption following diffuse brain injury in the mouse: clinical relevance to medically untreated concussion. Sleep 37, 743-752.
Harrison, J.L., Rowe, R.K., O’Hara, B.F., Adelson, P.D., Lifshitz, J., 2014. Acute over-the-counter pharmacological intervention does not adversely affect behavioral outcome following diffuse traumatic brain injury in the mouse. Exp Brain Res 232, 2709-2719.
Jiang, P., Franklin, K.M., Duncan, M.J., O’Hara, B.F., Wisor, J.P., 2012. Distinct phase relationships between suprachiasmatic molecular rhythms, cerebral cortex molecular rhythms, and behavioral rhythms in early runner (CAST/EiJ) and nocturnal (C57BL/6J) mice. Sleep 35, 1385-1394.
Duncan, M.J., Smith, J.T., Franklin, K.M., Beckett, T.L., Murphy, M.P., St Clair, D.K., Donohue, K.D., Striz, M., O’Hara, B.F., 2012. Effects of aging and genotype on circadian rhythms, sleep, and clock gene expression in APPxPS1 knock-in mice, a model for Alzheimer’s disease. Experimental neurology 236, 249-258.
Philip, V.M., Sokoloff, G., Ackert-Bicknell, C.L., Striz, M., Branstetter, L., Beckmann, M.A., Spence, J.S., Jackson, B.L., Galloway, L.D., Barker, P., Wymore, A.M., Hunsicker, P.R., Durtschi, D.C., Shaw, G.S., Shinpock, S., Manly, K.F., Miller, D.R., Donohue, K.D., Culiat, C.T., Churchill, G.A., Lariviere, W.R., Palmer, A.A., O’Hara, B.F., Voy, B.H., Chesler, E.J., 2011. Genetic analysis in the Collaborative Cross breeding population. Genome Res 21, 1223-1238.
Jiang, P., Striz, M., Wisor, J.P., O’Hara, B.F., 2011. Behavioral and genetic dissection of a mouse model for advanced sleep phase syndrome. Sleep 34, 39-48.
Philip, V.M., Duvvuru, S., Gomero, B., Ansah, T.A., Blaha, C.D., Cook, M.N., Hamre, K.M., Lariviere, W.R., Matthews, D.B., Mittleman, G., Goldowitz, D., Chesler, E.J., 2010. High-throughput behavioral phenotyping in the expanded panel of BXD recombinant inbred strains. Genes, brain, and behavior 9, 129-159.
Wisor, J.P., Jiang, P., Striz, M., O’Hara, B.F., 2009. Effects of ramelteon and triazolam in a mouse genetic model of early morning awakenings. Brain research 1296, 46-55.
Development
Mang, G. M., Nicod, J., Emmenegger, Y., Donohue, K. D., O’Hara, B. F., & Franken, P. (2014). Evaluation of a piezoelectric system as an alternative to electroencephalogram/ electromyogram recordings in mouse sleep studies. SLEEP, 37(8), 1383-1392. doi:10.5665/sleep.3936
Huffman, D. M., Staggs, K. E., Yaghouby, F., Agarwal, A., O’Hara, B. F., Donohue, K. D., Blalock, E. M., & Sunderam, S. (2016). Tunable somatosensory stimulation for selective sleep restriction studies in rodents. Conf Proc IEEE Eng Med Biol Soc, 2016, 1640-1643. doi:10.1109/EMBC.2016.7591028
Klefot, J. M., Murphy, J. L., Donohue, K. D., O’Hara, B. F., Lhamon, M. E., & Bewley, J. M. (2016). Development of a noninvasive system for monitoring dairy cattle sleep. J Dairy Sci, 99(10), 8477-8485. doi:10.3168/jds.2015-10695
Yaghouby, F., Donohue, K. D., O’Hara, B. F., & Sunderam, S. (2016). Noninvasive dissection of mouse sleep using a piezoelectric motion sensor. J Neurosci Methods, 259, 90-100. doi:10.1016/j.jneumeth.2015.11.004
Yaghouby, F., O’Hara, B. F., & Sunderam, S. (2016). Unsupervised Estimation of Mouse Sleep Scores and Dynamics Using a Graphical Model of Electrophysiological Measurements. Int J Neural Syst, 26(4), 1650017. doi:10.1142/S0129065716500179
Yaghouby, F., Schildt, C. J., Donohue, K. D., O’Hara, B. F., & Sunderam, S. (2014). Validation of a closed-loop sensory stimulation technique for selective sleep restriction in mice. Conf Proc IEEE Eng Med Biol Soc, 2014, 3771-3774. doi:10.1109/EMBC.2014.6944444
Donohue, K. D., Medonza, D. C., Crane, E. R., & O’Hara, B. F. (2008). Assessment of a non-invasive high-throughput classifier for behaviours associated with sleep and wake in mice. Biomed Eng Online, 7, 14. doi:10.1186/1475-925x-7-14
Williams DG, K. D., BF O’Hara. (2008). Low-Frequency Amplifiers for PVDF Film Sensors. Paper presented at the IEEE, Southeast conference.
Flores, A. E., Flores, J. E., Deshpande, H., Picazo, J. A., Xie, X. S., Franken, P., Heller, H. C., Grahn, D. A., et al. (2007). Pattern recognition of sleep in rodents using piezoelectric signals generated by gross body movements. IEEE Trans Biomed Eng, 54(2), 225-233. doi:10.1109/tbme.2006.886938
Bernat, R., Lin, A-H., Agarwal, A., Donohue, KD., O’Hara, BF. (2019). Piezoelectric sensors for noninvasive breath rate tracking in a cage setting. Society for Neuroscience annual meeting, Chicago, 2019.
Huffman, D., Duque Quiceno F., Carrizosa, S., Ajwad, A., Wang, J., Johnson, E., Hargis-Staggs, K., Donohue, K., O’Hara, BF., Bauer, B., Blalock, E., Sunderam, S. (2019). Toward high-throughput, non-invasive seizure detection using piezoelectric motion. Society for Neuroscience annual meeting, Chicago, 2019.
Topchiy, I., Fink, AM., Maki, K., Calik, M. (2019). Validation of PiezoSleep scoring against EEG/EMG sleep scoring in rats. Society for Neuroscience annual meeting, Chicago, 2019.
Ajwad, A., Huffman, D., Wang, H., Moore, I., Mills, R., Yaghouby, F., Gentry, M., Pauly, J., Bauer, B., O’Hara, BF, Sunderam, S. (2018). A noninvasive screening method for seizures and related behaviors in small animal models. Society for Neuroscience annual meeting, San Diego, 2018.
Huffman, D., Ajwad, A, Agarwal, A, O’Hara, B, Donohue, K, Sunderam, S. (2018). Automated selective REM sleep restriction through noninvasive somatosensory stimulation. Sleep Meeting, 2018, Baltimore, MD.
Huffman D, A. A., Agarwal A, O’Hara BF, Donohue KD, and Sunderam S. (2018). A non-invasive alternative to selective sleep restriction in rodents using somatosensory stimulation. Society for Neuroscience annual meeting, San Diego, Nov 2018.
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